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A second possibility is that GM1 is not required for the initial steps of CT binding and internalization, but is required for later steps in intoxication (i.e. the potential hand-off mechanism discussed in our response to item #6 above).
In a fit of design intoxication, I plonked down $500 for a perfect black pencil skirt, a reckless expenditure that launched me into nosebleeding panic for months afterward.
I learned loads more at Sue's, though too much of it was lost in the haze of intoxication; I always left wishing I had a tape of it all.
"Turning out Badly" offers a tale from her wayward adolescence, and seethes with fury at the world that was later to offer her such intoxication: "I was an intercontinental ballistic missile with an atomic warhead," she says of her teenage self.
I know the pleasures and joys of intoxication, I know the despair to which they can lead.
I knew I'd be made to feel guilty about my intoxication, I knew I'd be asked about my misguided decision to willingly get into the car and I already felt guilty and stupid about those things.
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This area of toxicology has undergone profound changes during the last decades: traditionally clinical toxicology was concerned with the diagnosis and treatment of acute intoxications (i.e. reduction of absorption, accelerated elimination, and antidotes).
The strongest coaggregation partners with Elizabethkingia spp. isolate CH2B were not other Gram-negative bacteria commonly found in the aquatic environment, i.e., Aeromonas or Flavobacterium spp., but rather organisms important in food spoilage and/or intoxications, i.e., S. aureus, L. innocua, L. monocytogenes, S. enterica, E. faecalis, and P. aeruginosa.
Adolescent males and females housed alone during the intoxication period (i.e. non-social context) showed ethanol-induced CTA only at a does of 2.0 g/kg.
I don't think we've reached that state of intoxication, and I don't think this painting has quite the popular appeal of the Van Gogh".
having reeled across the last ten pages with some moments of such intensity and intoxication that I seemed only to stumble after my own voice, or almost, after some sort of speaker. . . .
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com