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2, 3 Paradoxical sweating and heat intolerance was observed starting at age four.
The most severe glucose intolerance was observed with aging (Fig. 2c).
For example, McLellan and colleagues [ 21] identified 14 women with a previous diagnosis of GDM with both parents available for study and noted that glucose intolerance was observed in 64% of the parents.
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Neither local nor systemic signs of intolerance were observed [ 30].
Clinical manifestations of orthostatic intolerance are observed frequently in children, adolescents, and young adults and in older subjects.
Other than itching, experienced also in the control eye by one subject and determined to be unrelated to the study treatment, no signs of intolerance were observed.
In the first phase of this study, no signs of ocular intolerance were observed and no adverse reactions were reported in the first three treated subjects.
The CerS2‐null mice share similarities with the pathophysiological changes observed in patients or mouse models of diabetes mellitus, as insulin resistance and glucose intolerance were observed in CerS2‐null mice (Park et al., 2013).
After no signs of intolerance were observed in the subjects, the dose escalation phase of the study was initiated, and the remaining subjects received three times daily escalating doses of GS-101 in one eye for 14 days.
In fact, glucose intolerance and IR was observed in a few strains of rodents treated daily with high doses of rapamycin.
None of the following adverse effects such as hepatotoxicity, gastric intolerance and weight gain was observed.
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