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Levodopa works differently for different people, and often stops working or develops intolerable side effects.
Other pills have centred on altering hormonal mechanisms to produce dysfunctional sperm, but this is said to have "intolerable" side effects.
Sometimes a stent is indicated even in patients with stable coronary artery disease, he said — for example, when the medicine doesn't work or has intolerable side effects.
They said there was a pressing need for new drugs because, for many patients, other treatments either have intolerable side effects or are ineffective.
Other medications that might be advisable cause intolerable side effects, and the more drugs she takes, the greater the risk of dangerous drug interactions.
Before statins, doctors were virtually powerless to prevent such heart attacks because there were no drugs that were effective at reducing cholesterol without causing intolerable side effects.
However, these medications may have to be discontinued due to intolerable side effects.
Treatment in three patients was considered a failure due to intolerable side effects or failure to control uveitis.
Patients have cited a lack of efficacy or intolerable side effects such as severe depression and fatigue.
Patient could stop the first line antipsychotic when relapsing or due to the development of intolerable side effects and switch to a second line antipsychotic.
Patients, who stop taking a particular medication due to intolerable side effects, may not report a detailed history for that medication compared to medications they are currently taking.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com