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Subjects who experienced an intolerable response were permitted to be down-titrated only once by 20 mg/d to the next available lower dose.
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[Palin's] demagoguery has elicited some frightening, intolerable responses.
"Intolerable" responses required the subject to be tapered to a lower dose, if available.
His first book, The Divided Self, which presented schizophrenia as a rational response to intolerable experiences, was written at just 28.
He presented schizophrenia as a rational response to intolerable experiences – a view that put him at loggerheads with an establishment that saw mental illness as a medical problem – and encouraged residents of Kingsley Hall to embrace their so-called madness.
These are the moments when potential champions have to show they can cope when the heat of the battle is dangerously close to intolerable and Leicester's response to the early setback, hitting back with Danny Drinkwater's deflected effort and a goal for Andy King in first-half stoppage-time, was the perfect riposte to anyone thinking they may not be strong enough mentally.
Treatment continued until progression of disease, intolerable toxicity or maximum response.
Switching among them is common practice in patients who have had an inadequate response or intolerable adverse events.
Individuals with DSM schizophrenia, schizoaffective disorder, or delusional disorder and aged 18 65 years, whose treating clinicians were considering a change of antipsychotic due to lack of response, or intolerable side effects, were eligible for the study.
Despite the development of palliative care in France, most of those calling for the decriminalization of euthanasia or physician-assisted suicide do so in response to intolerable situations they have seen afflicting their relatives or friends at the end of life (report of the French National Ethics Advisory Committee, the CCNE)[ 14].
The studies included patients with ≥14 UI episodes per week due to NDO from SCI or MS. Study protocols required all patients to have been inadequately managed with at least one anticholinergic for their UI, defined as an inadequate response or intolerable side effects after >1 month on an optimized dose.
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