Sentence examples for intolerable events from inspiring English sources

According to the researchers in the Toronto Group [40], alexithymia should be considered a dimensional construct, meaning a stable personality trait, not a transient state in response to emotionally intolerable events, as McDougall [64] and Krystal [65] have claimed.

Former Supreme Court Justice Sandra Day O'Connor has said that the "execution of a legally and factually innocent person would be a constitutionally intolerable event".

And after death, both lay claim to what Grann calls the "grisly Holy Grail among opponents of capital punishment": a verifiable case of wrongful execution, what Sandra Day O'Connor once decreed a "constitutionally intolerable event".

In case of intolerable adverse events, lower doses were administered, followed by increased doses once participants recovered from the adverse event.

Hitherto often unreported, however, is the potential of a dose re-escalation in patients who earlier required a sunitinib dose reduction as a consequence of intolerable adverse events.

Sir, In agreement with Van der Veldt et al (2008) and sunitinib clinical trials (Motzer et al, 2007), we observe in our clinical practice a significant proportion of patients who ultimately need a sunitinib dose reduction as a consequence of intolerable adverse events that cannot be effectively managed otherwise.

Study treatment was discontinued in the event of disease progression during chemotherapy, intolerable adverse events or at the patient's request.

The main outcome measure was cost per quality-adjusted life year gained; time without pain or intolerable adverse events was also included as a secondary outcome measure.

An additional outcome measure was time without pain or intolerable adverse events as measured by discontinuation because of drug-related AEs, which is a modification of the "time without symptoms or toxicity" (TWIST) analysis.

Fourteen patients received previous chemotherapy, which had been withdrawn due to intolerable adverse events.

The treatment continued until disease progression, intolerable toxic events, or withdrawal of consent.