Wolpert, ceaselessly contemplating suicide, writes that his wife "became very angry and said my suicide would have an intolerable effect on her and my children.
However, these patients had – at some earlier point during the course of their disease – also received one or more pain-relieving drugs prior to NT, but had discontinued their medication because of lack of effect or intolerable adverse effects.
A significant proportion of patients develop intolerable adverse effects, primarily mucosal and skin effects, before the onset of therapeutic effects.
Unfortunately, this increase in dosage can lead to the potential for intolerable side effects and pill burden, thus affecting treatment tolerability and adherence (4).
Though widely used as first-line treatment for NDO, anticholinergics are not always effective or may have intolerable side effects, and many patients discontinue their use [ 12, 13].
These findings are likely due to the inability of the current medication to cure or effectively manage the condition without intolerable side effects.
Before statins, doctors were virtually powerless to prevent such heart attacks because there were no drugs that were effective at reducing cholesterol without causing intolerable side effects.
The most frequently cited reasons for discontinuing medication are the family's experience that the medications are not effective or the child is experiencing intolerable adverse effects.
With or without medication overuse, as defined by ICHD-2 No therapeutic or unsatisfactory effect 2. With significant disability, as defined by MIDAS ≥11 Intolerable side effects Contraindications to use .
