Intolerance is intolerable.
The currently available medications for symptomatic management of cough are inadequate due to lack of proven efficacy and their association of undesirable or intolerable side effects at anti-tussive dosage [ 3], suggesting that non-pharmacological therapeutic strategies may be vital to the successful treatment of cough.
Moreover, when the patients felt any intolerable adverse effects after decreasing the daily dosage of EE2 to 2.0 mg or 1.5 mg, the treatment was stopped.
However, a critical review of the article indicated that repeating FOLFIRINOX in the original dosage and treatment schedule is intolerable even in selected Japanese patients because the dose intensity of bolus fluorouracil was only 15.4%, and dose reduction and cycle delay were required by 88.9% of the patients.
Unfortunately, this increase in dosage can lead to the potential for intolerable side effects and pill burden, thus affecting treatment tolerability and adherence (4).
Such nonspecific therapeutic strategy induces chemo-resistance, which creates a situation of either further increasing chemotherapy dosage with more severe toxicity or making patients intolerable for treatment.
On the other hand, an early study by Muggia et al. [ 31] showed a high response rate (27%) for patients with platinum -resistant recurrent ovarian cancer using a high dosage of 50q3wks, but they also found an intolerable incidence of side effects, mainly PPE and stomatitis.
Interestingly, even with the reduced dosage of panobinostat, combination treatment with MD5-1 wastillll intolerable with mice succumbing earlier than vehicle-treated mice (median=18 versus 15 days, P>0.05).
Moreover, oral administration of AEDs at dosages high enough for adequate seizure control may be associated with intolerable systemic side effects.
The prescriptions should be clear, include preferably oral medications and a treatment regimen with regular times and dosages, followed by rescue dose of a second drug to be administered if the pain becomes intolerable (VAS >5 or intense pain on a simple verbal scale).
