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However, in many cells one of the nuclei moved into the protrusion, generating a functional daughter cell with normal ploidy.
The nuclear segregation into the new compartment often occurred independently of mitotic spindle elongation and might be a consequence of cytoplasmic flow into the protrusion.
Nuclei appeared to be carried into the protrusion by cytoplasmic flow, though it is possible that endoplasmic reticulum based nuclear connections to the plasma membrane could also contribute to nuclear segregation (Fig. 6; supplementary material Movie 11).
However, when protrusion appeared in cells that already contained two nuclei after a failure of cytokinesis, in 7/15 cells one of the two nuclei moved into the protrusion in the absence of the spindle and independently of mitosis.
Importantly, this sliding was always directed towards the protrusion, suggesting that in addition to cell geometry (Mishra et al., 2012) and secretion (Pardo and Nurse, 2003), other factors such us flow of membrane and/or cytoplasm into the protrusion may contribute to directional ring sliding.
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The aneurysm can be imperceptible during ventricular diastole, but become evident when the contraction of the left ventricle pushes the protrusion into the right outflow tract.
This study looks into the effect of the protrusion height on heat transfer and pumping power performance.
From the microscopic images, the length of the protrusion into the micropipette (Lp), the radius of the micropipette (Rp), and the radius of the GUV (Rv) were carefully measured.
Canal encroachment was assessed by magnetic resonance imaging, and the percentage of canal encroachment was calculated as the area of the protrusion into the canal of the injured vertebra divided by the mean of the maxim canal area of the adjacent two vertebrae on axial magnetic resonance imaging of the injured segment.
The atomic structure of the receptor-binding domain of SU fitted into the upper protrusion.
The Mo-RBD also fits well into the upper protrusion of the cryo-EM reconstruction of the IAS Env.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com