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The impotent struggle to prevail against conditions that won't yield can prove the unmaking of self-made men, and perhaps turn them into madmen now and then.
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Would it turn you into a madman, hellbent on genetically modifying stem cells into an eternal caviar production line?
From a persnickety, epicene bachelor, Warwick evolves into a madman running wild in his own home, and from there into a diabolical sociopath.
"You're just going round in circles in your head and turning into a madman," said Ferdinand, who also admitted that it wasn't how Sir Alex Ferguson used to do things.
Earlier in December Rio Ferdinand publicly questioned Moyes's policy of naming the team close to a match, rather than the day before, as Ferguson did, stating it could turn the defender "into a madman".
A French doctor injected calf's blood into a madman, who promptly started to sweat and vomit and produce urine the colour of chimney soot.
"It's gonna turn anybody into a madman," he added.
When madmen descend into insanity, it is their own illness.
In novels like "Libra," "Mao II," "White Noise" and the magnificent "Underworld," he has drawn a vivid fever chart of American history, showing us, often with uncanny prescience, how random violence and paranoia have insinuated themselves into the collective unconscious, how madmen and terrorists have used bombs and guns and the media to seize hold of the historical imagination.
Yet her cross-threaded tales of drifters, stranded motorists and madmen got its hooks into me.
Everyone else in the bar seemed to be erupting into laughter, their lives untouched by madmen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com