Translation initiation in eukaryotes is intimately regulated by a set of proteins known as eukaryotic initiation factors (eIFs), which exploit diverse functions from positioning of the initiator tRNA in the ribosomal P-site to the recognition of mRNA [1].
In addition, Cx43 is also intimately regulated by miRNAs at the post-transcription level [ 10, 11, 14].
The activity of histones is intimately regulated via the broad range of reversible, enzymatically catalyzed posttranslational modifications (PTMs) constituting a specific histone code.
Notably, in a similar manner, a close relative of BAX, the proapoptotic BCL-2 protein BID, has been previously shown to be modified via N-myristoylation, a process that intimately regulates its recruitment to MOM.
Given the fact that immune cells are able to intimately regulate vessel formation and function [ 32] and considering the essential role of FGF9 and integrin β3 in vasculogenesis [ 33] and angiogenesis [ 34], we postulated that formation and maturation of placental blood vessels might be impaired under conditions of ICP.
These merchant associations, or guilds, became intimately involved in regulating and protecting their members' commerce, both in long-distance trade and in those activities which catered to the needs of the town's inhabitants.
Given their role in modulating gene expression it is not surprising that miRNAs have been shown to be intimately involved in regulating a wide variety of biological processes, including proliferation, apoptosis, cell-cycle control, and differentiation.
Our findings provide evidence for SLE association with an X-chromosome region harboring two genes that are intimately involved in regulating the expression of methylation-sensitive genes and in innate immune response.
Thus, vitamin D appears to be intimately involved in regulating neurotrophins.
The Epac-Rap1 pathway is intimately involved in regulating cell migration and cell-cell interactions in a cell type dependent manner.
