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In conclusion, the design of molecules to impair intimate attachment of attaching and effacing pathogens to the intestinal mucosa will probably have an important effect on dangerous microorganisms of public health importance, and there is a possibility that virulence factor inhibitors will be effective for a long time before resistance becomes an issue.
Human virulent STEC strains often may also contain other virulence factors such as intimin (eae), a protein essential for the intimate attachment and the formation of attaching and effacing lesions on gastrointestinal epithelial cells, and E. coli hemolysin (ehxA) (2 ).
adhere to intestinal epithelial cells and deliver proteins into the host via the T3SS, resulting in microvilli effacement and intimate attachment to cells, forming the so-called attaching and effacing (A/E) lesions.
The Tir intimin interaction leads to intimate attachment and formation of the actin pedestal beneath attached bacteria (Croxen and Finlay, 2010).
In consequence, these ROP1 'clouds' reflect unsuccessful MJ-dependent intimate attachment.
The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion.
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To Ms. Scarf, who is seeking "those basic psychological truths about intimate attachments which cut across social and economic dimensions," this is enough.
Yet he was able to take those intimate attachments and transform them into something open, generous and elegant.
As STEC colonization progresses in human infections, intimate-attachment and Stx production contribute to the development of severe hemorrhaging.
And the sisters' intimate companionship develops into an incestuous sexual attachment.
Intimins, first described by Jerse et al in enteropathogenic and E. coli strains, promote intimate bacterial attachment associated with attaching-effacing lesion formation in the gut mucosa [8], [9].
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