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These results suggest that LGR5-positive cells in the intestine are true intestinal stem cells and that LGR5 regulates intestinal stem cell differentiation in mouse.
Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells.
Intestinal stem cells provide a new lining for the gut.
Lgr5 marks mitotically active intestinal stem cells (ISCs).
In this review, we describe the recent developments of in vitro intestinal stem cell cultures.
Cancer therapies utilizing chemotherapy or radiotherapy are constrained by risk of intestinal stem cell death.
These data provide in vivo quantification of human intestinal stem cell and crypt dynamics.
Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors.
Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging.
The relationship between intestinal stem cells (ISCs) and the surrounding niche environment is complex and dynamic.
Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans.
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