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JH has been shown to sustain ovarian maturation through pleiotropic actions on adipose and reproductive tissues (Flatt et al., 2005), but its intestinal roles remain to be established.
Such intestinal roles would be consistent with the finding of isolated insulin-producing secretory cells in the digestive tract of other invertebrates and protochordates (Sherwood et al., 2005).
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To explore the intestinal role of LIN-35, we conducted a genome-wide RNA-interference-feeding screen for suppressors of lin-35 ; slr-2 early larval arrest.
Consistent with a possible intestinal role, we detected transcript upregulation of the JH target Kruppel homolog 1 (Kr-h1) (Jindra et al., 2013) in guts of mated females.
This observation, coupled with two studies regarding Sjögren's syndrome (SS; Ewert et al., 2010; Nguyen et al., 2008), suggests a possible extra-intestinal role for GPA33 in barrier function.
McClellan, J. L. et al. Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1.
The intestinal epithelial role of Hnf4α is of less importance when disrupted during post-embryonic development of the gut [11].
In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.
This study demonstrates that GC-C, known primarily for its role in intestinal epithelial cell function, also plays an important role in the response to liver injury.
Yang, K. et al. Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.
Glutamine protects intestinal epithelial cells: role of inducible HSP70.
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