Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals.
These results suggest that both anti-CD40 MoAb and rmIL-12 induce an acute fatal toxicity characterized by similar intestinal pathology and mediated in part by IFN-gamma.
In vivo, oral inoculation of 50 µg/mouse L. acidophilus bacteriocin for 5 successive days resulted in a noteworthy decline of the intestinal parasite density, along with amelioration of intestinal pathology of infected mice.
Furthermore, in a number of studies, cross-sectional techniques, especially MRI, have been shown to be superior to SBFT for detecting small intestinal pathology [11, 12].
We found altered body weight, intestinal pathology, and bacterial translocation in spleen, liver, and gallbladder in chronically Salmonella-infected mice.
This study suggests that both prematurity and inflammation in utero disturb fetal gut development, potentially predisposing to postnatal intestinal pathology.
The susceptibility of HLA-DR3.IFN-γ−/− mice to D-galN sensitized TSS further underscored the significance of IFN-γ in eliciting the small intestinal pathology.
Our data demonstrates that HVEM-mediated stimulatory signals are essential for promoting innate and adaptive immune cell activation, pro-inflammatory cytokine production and intestinal pathology.
Infection of mice with these isolated strains displayed little to no intestinal pathology or inflammation, suggesting these bacterial strains are limited to cause only human enteropathology.
Taken together, our study suggests that IFN-γ-dependent small intestinal pathology and dysfunction, plays a significant role in the lethality of SAg-induced of TSS.
