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Intestinal location of AT2 receptors has previously been demonstrated [ 27, 28].
In having analysed only a single intestinal location, similar conclusions cannot be drawn from our data.
There was also no difference between tissue from patients with UC or CD, or in intestinal location (data not shown).
There were no differences in MMP8 expression in tissue from patients with UC or CD, or in intestinal location (data not shown).
In addition, tumor intestinal location may relate to different cell content of growth factors in tumors among right and left-sided CRC tumors [ 35].
Gold et al. reported the importance of intestinal location [ 19, 20] showing that intestinal GISTs are more likely to recur those gastric locations.
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This study cannot differentiate between these two, but demonstrates that this organism is adapted to survive and perhaps proliferate in various intestinal locations.
It has also led to new insights into the presence of particular species and strains in the human gut and their variance between intestinal locations and species of mammal.
It is certainly plausible that prior antimicrobial use would have affected results of this study; however, any effect would probably have been on overall prevalence, not an alteration of distribution of C. difficile in different intestinal locations.
While faecal samples provide a reasonable indication of the presence or absence of these organisms in the proximal intestinal tract, differences in C. difficile distribution and types can be found in different intestinal locations, something that must be considered when designing and interpreting studies relying on faecal sample collection alone.
Our work establishes that administration of glafenine larvae for 1 12 hours results in profound intestinal injury, with limited evidence of damage in extra-intestinal locations.
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