We have shown that C36B1.12 is probably expressed in head neurons and intestine; however, the intestinal expression might be ectopic (see Discussion for details), which would imply that the gene is exclusively expressed in neurons.
Eleven genes were reportedly expressed in the intestine, with 5 exclusively intestinal, although the significance of intestinal expression is unclear since this is a common site for promiscuous transgene expression in C. elegans [8].
The rescue with the intestinal expression was similar to that by a ubiquitously expressed raga-1 Q63L transgene (above).
When combining the intestinal expression profile of omentin (small and large intestine, intestinal adipose tissue) with the functional data on the recognition of bacteria-specific components in the host, omentin could be involved in intestinal defense mechanisms in CD.
In addition, L. acidophilus NCFM, administered orally as a probiotic, increased intestinal expression of cannabinoid and opioid receptors in mouse and rat intestines, and had similar effects in human epithelial cell culture 43.
SKN-1 in the intestine is activated in response to stress (e.g. arsenite) to increase intestinal expression of gcs-1 and other phase 2 detoxification genes.
However, we found no study in the literature investigating the intestinal expression of CD40 after TBI.
Importantly, intestinal expression of mitochondrial and cytosolic CK enzymes was shown to be attenuated in clinical IBD biopsies.
Hence, we designed the current study to explore the intestinal expression pattern of CD40 after TBI in rats.
Additionally, Chen et al. reported that transient intestinal expression of Pdx1, Ngn3, and Mafa promoted rapid conversion of intestinal crypt cells into endocrine cells (Chen et al., 2014).
B4galnt2 intestinal expression changes the gut microbiome and consequently facilitates epithelial invasion of Salmonella typhimurium, the underlying mechanism of which could be by increased intestinal inflammatory cytokines and infiltrating immune cells.
