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"I take care of children who have intestinal deficiencies, eating deficiencies, and they are very much at wits' end," Hackam says.
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Kirienko and co-workers demonstrated that LIN-35 and SLR-2 have redundant functions in the intestine because intestinal deficiency is seen only in double-mutant animals (another synthetic phenotype).
But the enzyme activities measured in the pancreas were much greater in Roe deer than in calf and this could compensate this intestinal deficiency in enzymatic digestion.
Although intestinal HSL deficiency markedly affected cholesterol homeostasis in the small intestine, the consequences on whole body lipid metabolism were only marginal.
► Intestinal HSL deficiency does not affect triglyceride metabolism.
The effects of intestinal ATGL deficiency on mitochondrial function are still elusive.
In the adult mouse infection model, GS readily causes intestinal disaccharidase deficiency, whereas WB infection does not (Solaymani-Mohammadi and Singer 2011).
We speculate that in the case of intestinal HSL deficiency less FC is pumped back out into the intestinal lumen and consequently more cholesterol can be found in the circulation 4 h post-gavaging.
Further data from this study revealed that intestinal ATGL deficiency has no influence on chylomicron production, suggesting that lipolytic products generated by ATGL are not used for intestinal lipoprotein production.
Many arrive with health problems seldom seen in this country — vitamin deficiencies, intestinal parasites and infectious diseases like tuberculosis, for instance — and unusually high levels of emotional trauma and stress.
Also some individuals develop altered gastrointestinal absorptive capacity following HCT as a result of gastrointestinal GVHD, intestinal bile salt deficiency, pancreatic enzyme insufficiency, or bacterial overgrowth; consequently, these individuals may have difficulty absorbing dietary fat and fat soluble vitamins such as vitamin D (24).
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