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All studies involved complex interventions with multiple components.
TCM is characterised by both pre-emptive approaches and interventions with multiple components.
There are considerable overlaps between different categories, and interventions with multiple components were common.
The most positive outcomes were linked to interventions with multiple components and where community engagement had occurred.
1 2 Almost all changes to practice in primary care involve 'complex interventions', that is, interventions with multiple interacting components.
Several community-based interventions with multiple activities, including awareness raising, sensitization and community participation and interaction, and peer support groups demonstrated significant changes in developing countries [ 1, 39].
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By generating diversity within the viral population, the high rate of mutagenesis facilitates continuing HIV survival in the host, even when the virus faces a complex selective environment that includes: 1) limited target cell availability and susceptibility, 2) the presence of vigorous antiviral immune responses, and 3) host intervention with multiple antiretroviral therapies [2] [5].
The U-CARE program is a complex, multifactorial intervention with multiple components.
The Pac-IFicO programme is a complex intervention with multiple components.
Such a finding also adds weight to the notion that TA is a complex intervention with multiple causal pathways.
12 15 ACP is a complex intervention with multiple components that, like advance care directives, varies considerably 4 6 throughout the world.
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