The evaluation of complex interventions should, where possible, facilitate not restrict that complexity.
In order to facilitate and support a step change in aphasia research, we need to look to the methodological literature on the reporting of complex non-pharmacological interventions and where possible contribute to that knowledge base.
In the event of 'no intervention effect', where possible, a sub-analysis will be conducted to compare outcomes in the control group carers who did not have a meeting (i.e. a 'per protocol' analysis) with those in the intervention group carers who had a meeting.
Effect sizes of interventions were calculated where possible (mean difference of intervention and control divided by the standard deviation of the control at baseline) for intervention versus control studies or exercise versus decompressive surgery studies.
Parameters relating to the natural histories of diseases, the effectiveness of interventions and the impact on HRQoL of diseases and interventions were sourced, where possible, from national statistics and published literature.
Participants who dropped out before receiving the intervention were substituted where possible, to ensure the courses were run with adequate numbers of participants, but these individuals will not form part of the analysis set.
The choice of interventions should be informed where possible on established crime prevention concepts and methods as well as evidence informed therapeutic interventions.
Where possible, interventions related to TB or HIV adherence were identified.
It is clear that targeting individual behaviour will not be sufficient to greatly increase active travel; where possible, interventions should also target organisational changes (i.e. policy and physical environment) in order to bring about a significant shift in transport mode among employees.
Conservation of these sensitive and vulnerable habitats requires the recognition of climate change effects so environmental managers can develop and apply appropriate intervention and adaptation strategies where possible.
