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The aforementioned interventions were studied in depth to help us structure our own intervention.
Patients were kept unaware that two different interventions were studied; both groups were given exactly the same information and questionnaires.
Similarly, pharmacological interventions were studied in the majority of RCTs; although 27% of RCTs studied devices, there were no trials focused on renal replacement therapy or extracorporal membrane oxygenation.
The strengths of the study lie in its longitudinal, randomized controlled trial design, the large sample size, and the real-world setting in which the interventions were studied, as urged by Rabin et al. [ 9].
The largest number of interventions was with drugs (18 English reports; 11 Japanese reports; 29 in total, 63.0%) followed by modes of care (9 English reports; 3 Japanese reports; 12 in total (26.1%)); other interventions were studied in less than 5% of reports (Table 3).
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Valid health-related quality of life (HRQL) measures are necessary to quantify the burden of TBI, functional impairment in survivors, and the impact of interventions being studied.
A wide range of interventions was studied (table 2).
During this 8 weeks period, the effect of four types of interventions was studied simultaneously.
In pragmatic trials the effectiveness of interventions is studied like they present in daily practice.
Masking at the time of intervention was not possible due to the nature of the interventions being studied.
The same type of interventions was studied in several countries, and different sources of information were used to corroborate results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com