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An overweighting of single studies within the meta-analysis (i.e., bias) due to this approach was, however, not expected, as the loading conditions between the separate interventions were different and independent.
However, we believe that the inclusion criteria, subjects, and interventions were different among the included studies, and might have impacted the results.
As the examples of studies in Nepal [ 3], Chile [ 4], and Ghana [ 5] show, the set of criteria identified for using in priority setting of health interventions were different between countries.
The processes involved in the interventions were different however, the aim of both interventions was to improve team functioning and involved strategies such as audit, feedback and team training> The SR addressed 3 of the 11 AMSTAR criteria.
Although the three interventions were different, in all three groups, the participants similarly increased the consumption of vegetables and decreased intake of snacks, sugared beverages, and processed foods, suggesting a common denominator of healthful dietary patterns across all groups compared with baseline (5).
This led us to compare microarray data generated from fat bodies overexpressing Sir2 with those obtained from fat bodies of animals subjected to DR. As the induced transcriptional changes of both interventions were different our data did not confirm this hypothesis.
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Third, a growing literature suggests that responses to interventions are different in different species due to in principle differences in initial conditions of complex systems (the organism) resulting in different genomic (and hence functional) outcomes [3],[32] [37][37].
The alternative to this explanation is that responses to interventions are different in different species due to in-principle differences in initial conditions of complex systems (the organism) resulting in different genomic (and hence functional) outcomes [ 46– 51].
Third, a growing literature suggests that responses to interventions are different in different species due to in principle differences in initial conditions of complex systems (the organism) resulting in different genomic (and hence functional) outcomes [ 3],[ 4],[ 32]–[ 37].
The two interventions are different in both length and content.
The two interventions are different educational sessions, conducted in the middle of pregnancy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com