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SUBJECTS AND INTERVENTIONS: We selected randomized controlled trials of interventions to improve adherence to medications used for preventing or treating cardiovascular disease or diabetes.
As the current study was more focused on basic pathophysiological mechanisms and not (yet) therapeutic interventions, we selected a model without antibiotics for the initial set of experiments.
When all three interventions in a trial network were active interventions, we selected A and B according to the estimates' precision, which might have contributed to the observation of more statistically significant results from the direct comparisons.
Based on models of aetiology of mood and anxiety disorders as well as mechanisms of change during interventions, we selected potential mediators and moderators of treatment outcome, namely coping, parent child interaction, self-associations, optimism/pessimism, temperament, and emotion processing.
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To be able to adequately compare the placebo versus melatonin intervention, we selected an RCT-design.
However, referrals have always been registered and for this intervention we selected the period from 2001 onwards.
Given the difficulty of monitoring each and every activity within this complex intervention, we selected, in collaboration with the Redesigned CHF implementing team, a restricted series of 24 activities, judged as constituting the core of the intervention (Table 1).
In order to explore the processes and practices involved in successful intervention, we selected two primary schools (ages 5 11 years) where the school rated the project as successful in enhancing participants' personal wellbeing and where the same arts practitioner had been involved throughout.
To increase the flexibility of this intervention package, we selected interventions that could be delivered individually or in group format.
From the studies with multiple intervention groups, we selected groups for which exposure in vivo was an important part of the intervention (intervention groups) and compared the outcome scores of these groups with the outcome scores of groups without exposure (control groups).
These articles were selected randomly for most subcategories, although in the large intervention subcategories, we selected six which showed the diversity of content of the subcategory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com