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Wycherley et al. [74] demonstrated that while both diet and diet with aerobic exercise improved oxidative stress and NO availability and significantly reduced body weight, no difference between interventions was observed after 12 weeks in obese individuals with T2DM.
Based on the aetiological hypothesis of Kaschin Beck disease (KBD), different interventions were adopted, and the preventive and therapeutic effects of interventions was observed and evaluated in this trial.
An uneven distribution between countries regarding the number of interventions was observed.
No significant interaction effect of receiving both interventions was observed, thus the main effects for each intervention are reported (Table 4).
The effect of these interventions was observed in men and not women because of the historical difference in smoking prevalence by gender [ 15, 24, 25].
In addition, a similar effectiveness of both exercise interventions was observed in the first 24 h and second 24 h of the 48-h assessment period (Fig. 3 A ).
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The interventions were observed by one of the authors (EV).
A sample of sessions of both interventions is observed for quality control purposes.
No differences in acceptance rates (dropout rates) or long-term effects between combined treatments and pure pharmacological interventions were observed.
No differences in acceptance rates and the long-term effects between combined treatments and pure pharmacological interventions were observed.
Screen failures or protocol deviations during the randomised interventions were observed in a further seven patients (see web appendix 1)—these patients were included in all analyses.
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