This decision is related to the fact that different techniques are likely to have different mechanisms of action and that it is generally not possible in such interventions to isolate the contribution of different components to the measured outcomes.
Evidence and experience suggest that in pandemic phase 6 (increased and sustained transmission in the general population), aggressive interventions to isolate patients and quarantine contacts, even if they are the first patients detected in a community, would probably be ineffective, not a good use of limited health resources, and socially disruptive.
Because of the high case-fatality rate and propensity for further transmission, a case of MHF is considered to be a public health emergency of international concern and requires prompt intervention to isolate the case-patient and trace and monitor all contacts for early signs of disease.
Recent research on the components of behavioral interventions has called for better intervention designs to isolate the individual components or techniques that are effective in bringing about a change in behavioral outcomes and to explain the mechanisms behind the effects through appropriate mediator variables [ 21- 24].
When a well which produces by more than one production zone starts to produce with excessive basic sediment and water (BSW), it is necessary to make an intervention on it to isolate the zone with high water production.
Since approval by the WHO in the early 2000s, ACT scale-up has frequently occurred in parallel with other transmission-reducing interventions, making it difficult to isolate the impact of each intervention independently.
Studies that combined GT or GTE with antihypertensive drugs, or any other dietary supplements, or other lifestyle interventions will be excluded, because we want to isolate the intervention effect due to GT and obtain its efficacy by direct comparison with placebo in the absence of any other hypertension intervention.
However due to the non-specificity of these interventions, it has been difficult to isolate the component that initiates the reinforcing behavior, which may eventually lead to addiction.
The buffer zones helped to isolate the intervention from control sectors and served as reservoirs to absorb any repellent effect the ITPS might have on mosquito populations, which might otherwise inflate the real intervention impact.
The main reasons for exclusion were: the age of the study population was not in the required range, lack of randomized controlled trial design, no focus on primary prevention, absence of behavioral outcomes, or the computer tailoring was part of a multicomponent intervention that made it impossible to isolate the effect of tailoring.
To isolate and measure the intervention effect on each measure of interest, we will fit a mixed-effects model to the data.
