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Tuberculosis is a leading cause of global childhood mortality; however, interventions to detect undiagnosed tuberculosis in children are underused.
Only one systematic review focused on interventions to detect cancer treatment-induced cardiotoxicity [ 36].
Disappointingly, few interventions to detect problems late in pregnancy and during labour are supported by rigorous evidence from RCTs.
The costs of screening interventions to detect hearing and vision impairment not only include the costs of the screening activities but also costs of hearing aids and glasses for those who need them.
The requirement for standardised protocols for participant selection, randomisation and the reliance on 'uniform' [ 9] interventions to detect ever smaller intervention effects has resulted in time consuming and financially expensive multi-centred studies.
Appropriate trials should be conducted to examine if early interventions to detect and treat systematically renal insufficiency and anemia in patients experiencing a first stroke may improve survival and quality of life.
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Therefore, within our clinical context, COS seems to be a promising intervention to detect and treat early difficulties in the development of secure attachment relationships.
Therefore, it is also important to include patients with a medical emergency team (MET) intervention to detect AEs with an unplanned need for a higher level of care.
The data were collected at multiple instances over time, before and after an intervention, to detect whether the intervention had a significantly greater effect than the underlying secular trend.
Assuming a small-moderate correlation (r = 0.4) between baseline and post-intervention, to detect a mean difference of 0.5 standard deviation between study groups (small-medium effect size) for the main dependent outcome (i.e., PA behaviour) at post-intervention [ 41] the required sample size is 100 participants per group, allowing for a 20% loss to follow-up (power = 0.80; alpha = 0.01).
Findings on inflammation and fibrosis would be given their warranted importance, with research in anticancer therapies focusing on suppressing the PCN state with very early intervention to detect and quantify any subclinical inflammatory change and to treat all levels of chronic inflammation and prevent fibrotic changes, and so avoid the transition from a normal cell to a cancer cell.
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