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Pharmacologic inhibition with well-tolerated interventions that inhibit or reduce activity of methyltransferase and histone deacetylase proteins may reduce abnormal hypermethylation of key tumour suppressor gene promoters, thus reducing or delaying neoplastic transformation.
Since prior sound exposures that induce TTS (or greater pathologies) can increase hair cell uptake of gentamicin in vivo, interventions that inhibit trafficking of aminoglycosides into the cochlea likely represent one potential clinical strategy to prevent sound-then-drug ototoxic synergism.
Interventions that inhibit SP signaling pathways generally show antinociceptive effects in animal models [ 35, 36].
Therapeutic interventions that inhibit apoptosis of renal tubular cells have the potential of minimizing deterioration of renal function.
Genetic interventions that inhibit IIS often result in enhanced resistance to various stresses including oxidative stress (Clancy et al., 2001; Broughton et al., 2005).
Both genetic and pharmacological interventions that inhibit the TOR pathway exhibit a similar phenotype, which is not further amplified by CR.
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Hence early detection of EBI may make it possible to predict patient outcome; logically, therefore, early intervention that inhibits such changes may decrease mortality and improve overall outcome.
Altogether, these data strengthen the notion that therapeutic interventions that effectively inhibit bone resorption could potentially be used as DMOADs.
Accordingly, during perioperative period, especially for hyperglycemic patients, interventions that may inhibit endothelial adhesion molecules expression are potential strategies to protect endothelial cells from dysfunction and its sequelae.
It prescribes that interventions should target systemic problems that inhibit the system from functioning well.
Thus, the focus of putative therapeutic interventions have shifted towards unraveling compounds that inhibit the earliest stages of Aβ42 oligomerization.
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