It has been shown that it is often unwise to base diagnostic, prognostic, preventive, or therapeutic interventions on data from one or few trials [ 1, 9, 10, 26, 75], and our recommendations do not in any way change this.
Intervention time series analysis models the effect of known interventions on data of counts of events collected regularly in time [ 16, 17].
A focused policy intervention on data sharing coupled with the development of a robust national database management system would be a viable strategy in the medium and long term to collate key missing data from the expanding private healthcare sector that would enable effective policy planning and optimization of healthcare resources.
Failing this, it is possible to model effects of different interventions, or combinations of interventions, based on data from cross sectional studies.
We illustrate this method with an analysis of 'audit and feedback' interventions, based on data from a Cochrane review.
Given widespread adoption, such guidelines should make it possible to compile AMR trends, highlighting variation between regions and guiding the implementation of focused interventions based on data from what would otherwise be scattered amongst reports.
To understand the effect of the intervention on data-informed decision making, we implemented a second PRISM assessment in 2012 – 4 years after the first PRISM assessment (23).
Although the PROGRESS registry was not specifically designed to assess the use of DrotAA, it was one of a number of therapeutic interventions on which data was collected.
Although the PROGRESS registry was not specifically designed to assess the use of low-dose corticosteroids, their use was one of a number of therapeutic interventions on which data were collected.
As PrEP gained visibility in the years following its debut, Weinstein and the AHF expressed deep skepticism about the treatment's potential as a community-wide intervention, based on data that showed men who enrolled in early studies had a poor track record of adhering to its once-daily dosing.
Our analysis does not aim to model any specific programme, but rather a 'generic' parenting intervention, drawing on data on a variety of evidence-based programmes that are likely to be implemented in the English context.
