The American Thoracic Society guidelines define severe asthma as asthma that requires high-dose inhaled and/or systemic corticosteroid treatment and that, despite these interventions, is characterized by persistent and/or life-threatening symptoms [37].
The statistical pooling of the subgroup of surgical pathway interventions is characterized by a considerable overall test-value for statistical inconsistency (I2 = 60.9%) which also reflects the clinical heterogeneity of the surgical pathway interventions included in this comparison.
In the main task, interventions were characterized by the initial QALE of the target groups.
These interventions were characterized by self-monitoring, encouragement and peer support, with varying levels of intensity and structure.
Patients not returning to work after the interventions were characterized by negative expectations, perceptions about pain and disability, and previous physiotherapy treatment.
However, in practice, lean interventions are characterized by high variance; that is, high heterogeneity of the context and the intervention itself - the content, the application and the outcomes of lean [ 5– 9].
This group of interventions was characterized by a structured, 6- to 12-week CBT-based approach, with five of the studies involving a 'live' therapist either online [ 55, 64, 65, 81] or in additional face-to-face groups [ 60].
These interventions were characterized by single or multiple training sessions involving multiple 'modes' of delivery (e.g., video, role-play, etc)., but did not have an 'exchange' component whereby recipients interacted with facilitators (e.g., researchers, other experts) to engage with the knowledge.
In Fig. 2 a possible healthcare intervention is characterized by five attributes: length of life, activities of daily living, side effects, cost, and duration of treatment.
The proposed integrated model of systemic inflammation prior to any intervention is characterized by the dynamic state of eleven (11) variables that describe the propagation of LPS signaling through interacting modules.
The dynamic hysteresis loop of the tumor population density against an intervention in figure 1 also indicates that the dynamic growth and regression of a tumor system, when modulated by an external intervention, is characterized by a sort of hysteretic metabolism.
