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Our procedures for generating the candidate interventions involve a series of interactions between the research team and local stakeholders, actual and potential service users from our exemplar groups, and a panel of national and international academic experts in the field of primary care mental health (see Figure 1).
Some interventions involve a series of personal requests from loved ones to ask the addict to enter detox therapy and rehabilitation, while others involve reading letters to the addict aloud or sharing personal feelings about the difficulty of seeing a loved one suffer from addiction.
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Both interventions involved a training session and then repeated daily use of compact disc recordings for 7 days.
All five studies were conducted in specialty care clinics, with three interventions involving a nurse practitioner or systems navigator and two interventions involving physicians.
Interventions involving a powder, extract or concentrate were also excluded.
No interventions involving a substitution with a fluoroquinolone have been reported.
The interventions involved a multifaceted, evidence-based, tailored practice-level intervention with a Practice Facilitator, and a patient-level intervention involving a one-hour visit with a Prevention Practitioner where patients received a tailored 'prevention prescription'.
In the field of diabetes, the review by Shojania [ 22] showed that multifaceted interventions provided a larger effect than interventions involving a single component.
The Cochrane review of the effect of placebo interventions involved a thorough search for trials including a no-treatment arm and a placebo arm.
Of these, 42 related to interventions involving a change in visual input or function: 5 controlled trials, 8 before and after studies and 29 case reports.
Of those interventions involving a home-based component, only one study reported using influential factors in the home environment, by asking a parent to adopt an active lifestyle and thus provide their child with an active role model 8, 34.
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