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Accordingly, interventions including legislative reforms, interventions targeting workers, and interventions including modifications of vehicles have been excluded in this review.
In the wider population there is evidence that lifestyle or behavioural interventions including modifications of diet and/or physical activity can help with weight loss even in the longer term [ 23- 27].
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Lifestyle interventions, including dietary modifications such as alcohol consumption, have gained popularity as explorations in symptom management.
Comprehensive lifestyle interventions including behavior modification produce significant treatment effects in children (70).
A range of interventions, including lifestyle modification programs and/or pharmacological treatment, can improve diabetes outcomes.
The potential value of "tissue protective" interventions including favorable modification of myocardial metabolism has long been recognized as well (Maroko et al. 1972).
Randomized trials of lifestyle interventions including dietary modification have demonstrated reduced incidence of diabetes in high-risk individuals 5 and improved cardiovascular disease risk factors in those with established diabetes 6, 7.
Evidence for the benefits of comprehensive lifestyle interventions including behavioral modification, currently based primarily on studies of white middle-class children, needs to be expanded through more studies targeting children of lower SES and non-white race/ethnicity.
Induced OA in animals may also be more progressive in males such as following DMM in mice [ 58], and as a result the majority of murine DMM studies are done in males with direct comparison of OA outcome measures or interventions (including genetic modification) in females being uncommon (for an example, see [ 59]).
For example, in Australia the Fit-4-Fun intervention which included modifications to the recess environment and prescribed family engagement activities to complement the curriculum intervention component, reported improvements in BMI, BMI z-score, and PA [ 76].
Although the amount of research in the field of work disability and return to work (RTW) has steadily increased, 11 there is still limited evidence on the effectiveness of interventions targeted at RTW. 12 Some workplace-based interventions, including either work modifications and/or involvement of workplace key stakeholders (eg, worker, employer, RTW coordinator) have shown promising results.
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