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Instrumental variable methods will be used to estimate the efficacy of the interventions in the presence of non-compliance.
To assess the impact of non-adherence, we propose to explore using instrumental variable (IV) methodology to estimate the efficacy for our interventions in the presence of non-adherence [ 39, 40].
Studies investigating the efficacy of psychotherapeutic interventions in the presence of pharmacological therapy (or vice versa) were excluded, as were those evaluating the efficacy of complementary and alternative (CAM) medicine (including meditation) or information/education strategies.
Nutrition intervention studies in hip fracture routinely report highly constrained research environments in order to demonstrate clinical effect of highly controlled, often one-dimensional interventions in the presence of these confounders, despite the recognised need for these patients to receive 'comprehensive' (that is, multidisciplinary and multimodal) care [ 2].
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A classic example of public intervention in the presence of a positive externality is the introduction of a policy of mandatory vaccination.
In the case of complex adaptive systems, several latent mechanisms could be present within the system, which can be triggered by the intervention in the presence of specific contextual elements and result in the observed outcomes [ 18].
The reduced or absent response of villous architecture to our nutritional intervention in the presence of HIV suggests this is a distinct pathophysiological condition, where HIV infection alters the sequelae of EE.
Such a study, in simple terms, would try to resolve the research problem of the value of nutritional intervention (restriction of polyphenols in maternal diet) against no intervention, in the presence of fetal ductal constriction without history of prenatal exposure to NSAID.
During this pretest participants worked through the intervention in the presence of a researcher, who stimulated participants to think aloud and asked in-depth questions to check the comprehensibility of the information, such as 'Can you explain in your own words what you have read?'.
At an optimum, marginal health gains for the last dollar spent should be equal for all interventions although, in the presence of a wide range of epidemiological, medical, political and socio-economic disparities, setting priorities for public spending could be difficult.
This is to allow assessment of relative effects of the malaria intervention variables in the presence of the variables used as controls in the study.
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