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Breaking the nexus between viral respiratory infections and asthma may be possible with interventions designed to inhibit atopy-related effectors mechanisms from participating in the host response to respiratory viral infections.
Moreover, several pharmacologic agents and genetic interventions designed to inhibit the execution of cell death often fail to do so when administered in a therapeutic (as opposed to prophylactic) manner, at least in the mammalian system, yet efficiently change its morphology.
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Recent studies have confirmed this possibility by showing that pathology in mouse models of amyotrophic lateral sclerosis, congenital muscular dystrophy, oculopharyngeal muscular dystrophy and collagen-VI deficiency, but not Duchenne muscular dystrophy, is significantly ameliorated by genetic or pharmacological interventions that have been designed to inhibit apoptosis.
The clusterin protein is an inhibitor of apoptosis with a cytoprotective function [ 2] and thus represents a promising target for molecular intervention strategies such as antisense therapy designed to inhibit its expression [ 3].
Another possible intervention with which to inhibit estrogen-related receptor alpha activity would be a drug designed to inhibit the activity of the intracellular signal transduction proteins responsible for activation of the receptor by phosphorylation.
Our results indicate that RGC apoptosis induced by optic nerve injury involves activation of caspase-2, and that synthetic siRNAs designed to inhibit expression of caspase-2 represent potential neuroprotective agents for intervention in human diseases involving RGC loss.
Gleevec was originally designed to inhibit a receptor kinase called PDGFR-beta, which is hyperactive in glioma, a brain cancer.
I suppose the routine was originally designed to inhibit boredom, and also to earn money.
The enzyme activity was inhibited by urea-based compounds originally designed to inhibit the mammalian sEH.
RO5126766 was designed to inhibit ERK signaling outputs more effectively than standard MEK inhibitors [28].
Indeed, the modes, to be discussed later, were not designed to inhibit reasoning.
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