A randomized placebo-controlled trial was designed to compare the efficacy of 26-week intervention, composed of either 2.2 g/day of n-3 PUFA, or olive oil placebo, with regard to symptom severity in first-episode schizophrenia patients.
A randomized placebo-controlled trial named OFFER was designed to compare the efficacy of a 26-week intervention composed of either 2.2 g/day of n-3 PUFA or olive oil placebo with regard to symptom severity in first-episode schizophrenia patients.
The only study that reports an intervention composed of EPA + DHA was conducted in ultra-high risk patients.
Moreover, a 12-week RCT conducted in individuals at high clinical risk of schizophrenia provides preliminary evidence that intervention composed of 1.2 g of PUFA (i.e. EPA + DHA) could prevent transition to first-episode psychosis.
Since continuing education workshops are a complex intervention composed of several interacting components [ 15, 16], the research team proposed that the project leaders begin by developing the theory underlying their interprofessional educational intervention.
A recent trial [ 78] investigated the effects of an evidence-based comprehensive weight loss intervention composed of diet, physical activity and behavioural therapy compared with standard therapy in obese asthmatics.
Most studies assess an intervention composed of only EPA, one study compared EPA and DHA in two separate study arms and only one study used a mixture of EPA + DHA.
A randomized placebo-controlled one-center trial will be used to compare the efficacy of 26-week intervention, composed of either 1320 mg/day of EPA and 880 mg/day of DHA, or olive oil placebo with regard to symptom severity and relapse rate in first-episode schizophrenia patients.
To fill these knowledge gaps, we developed a home-based walking therapy intervention composed of a counseling-for-exercise intervention (delivered biweekly), two walking training sessions with an instructor (delivered within 2 weeks of randomization), and individual and group walking in the community.
The purpose of this study is to determine whether a more intensive intervention composed of provider education and reimbursement for a package of caries-control services increases the delivery of caries-control services and reduces restorations among at risk children with capitation dental coverage.
