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Using a robust methodology, this group found no support for the perspective that individualised and clinically reasoned interventions are superior to generically applied interventions.
Our results indicate that this is a realistic goal in this population, although further research is still required to determine whether certain treatment modalities (or combinations of treatment interventions) are superior to others in achieving higher remission rates.
Active lifestyle interventions are superior to passive lifestyle modification advice (7) and ought to be studied more extensively, but we fully agree that they should be incorporated into any structured NODAT prevention program (6).
In designing this study, which has an active control group in Phase 2 (see Figure 1), we considered it unethical to have a non-treatment control group given that most RCTs of pediatric obesity lifestyle interventions show that such interventions are superior to control conditions [ 8].
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There was some evidence that externally-delivered interventions were superior to those delivered by school staff for depression, but not anxiety.
This heterogeneity of response may be "quantitative", where one of the interventions is superior to another in all the subgroups or "qualitative" when one of the interventions is superior in some subgroups and worse in others [ 39].
In this way, we wanted to test the null hypothesis that neither of the interventions is superior to the other.
Clinician- and parent-reported outcome measures showed that psychosocial interventions were superior to WL/TAU control conditions at post-treatment.
While both interventions were superior to self-care, our mediator analysis showed these benefits were not well explained by our measured "mediators".
Clinician- and parent-reported outcome measures showed that psychosocial interventions were superior to waitlist and treatment-as-usual control conditions at post-treatment.
Clinician- and parent-reported outcome measures showed that psychosocial interventions were superior to WL/TAU control conditions at post-treatment and individual therapy seemed to be more effective than group treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com