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Although skilled attendance at delivery is widely regarded as the main strategy to reduce maternal and perinatal deaths, there is less certainty on the optimal configurations of interventions and timing for different health system contexts in order to achieve ultimate health gains.
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One report emphasised the importance of effective caregiver support and early health promotion for care recipients, monitoring high risk groups, and timing interventions [ 37].
Thus, items on compliance, distribution of co-interventions and timing of outcome assessment are given the same weight as concealment of allocation, which, along with blinding, has been documented as the most important safeguard against bias [ 3, 4].
30 Quantitative synthesis was conducted in line with the protocol on comparable key outcomes across trials evaluating similar interventions (nature of intervention, and timing of assessments at approximately 3 months and/or 12 months post-injury or intervention).
In accordance with the protocol, quantitative synthesis was conducted on comparable key outcomes across trials that had similar interventions (nature of intervention) and timing of assessments (at approximately 6 months, 12 months and 2 years post-surgery).
Sequencing and timing integrated interventions is a critical consideration to intentional design.
Taken together, this observation highlights the need to strengthen the existing ANC, and timing the interventions to reduce syphilis related adverse pregnancy outcomes.
The studies differ in type of intervention, dose and timing of intervention, and the research is primarily based on case studies and studies with few and heterogeneous participants [ 36].
If disease specific outcome is considered the primary outcome after fast-track THA, clear goals for the rehabilitation must be established before patient selection, intervention type and timing of intervention can be made.
Comparability of interventions, outcomes and timing of assessments, and risk of bias were considered to determine potential for appropriate quantitative synthesis of the trials.
Two of the authors (CT,FC) independently applied the inclusion and exclusion criteria to each trial and then extracted data regarding details of the patients (number, mean age and age range, inclusion and exclusion criteria), details of the interventions, nature and timing of outcome measures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com