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The current practice of not requiring formal informed consent for some benign medical interventions and studies raises interesting questions about the ethical justification of informed consent.
Nevertheless, there are some concerns derived from the heterogeneity of interventions and studies [ 32].
This cannot be taken as a final proof of concept, but should encourage the development of further interventions and studies containing a greater number of patients.
The detailed mapping of malaria infections in these quarters at high-risk is therefore a matter of urgency, to guide targeted interventions and studies [ 48, 49].
For this to be achieved, standardized measurements using the same scoring procedures should be used to allow for comparison between various interventions and studies.
We recommend that, to determine measures of disease severity and control, effective interventions and studies should be built around carefully phenotyped patients and strictly follow carefully crafted methodological standards.
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There was significant heterogeneity among the interventions and study designs.
Analysis focused on: types of interventions and study outcomes.
Supplemental Table 1 provides descriptive data on the studies, interventions, and study quality.
TC designed the interventions and study forms under the supervision of HW and HP.
41 The interventions and study methods are described in detail elsewhere.
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