The ethics of undertaking the systems improvement intervention and analysis and dissemination of the findings were evaluated by the Office of Human Research Ethics of the University of North Carolina at Chapel Hill.
Reasons for drop out were independent of the intervention and analysis was performed on complete data.
By using a unit of randomisation, intervention and analysis that is logistically and administratively coherent, spill over can be minimised.
All studies on ECPR, including our study, have different inclusion criteria and methods of intervention and analysis under different healthcare environments.
The intervention and analysis were at the system level; we did not investigate individual patient characteristics and how they affect adherence.
In most pragmatic trials, the unit of randomisation, intervention and analysis is the cluster: the community or a segment of it.
The avian yolk sac endoderm, easily accessible for experimental intervention and analysis, may be a valuable animal model for such investigations.
Quantitative methods such as household interviews before and after the intervention, and analysis of school- and community-based injury surveillance were used to measure change in child caregivers' injury knowledge, attitude and behaviour, and child injury morbidity and mortality.
The paediatric diabetes centre will be the unit of randomisation, cluster, intervention and analysis, because that is where the intervention is aimed, though the effect will be evaluated at the patient level.
The study had to meet certain quality standards, which includes having a description of the intervention and analysis, detailing the time and location of data collection, and clearly stating the year and currency of presented costs.
