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Interventions A single topical dose of chloramphenicol (n=488) or paraffin ointment (n=484; placebo).
In training interventions, a single endpoint as an outcome requires a lot of interpretation, and potential criticism.
They designed a randomised crossover study with three interventions: a single bout of endurance exercise, a single bout of resistance exercise and a control period.
Participants will be randomized with equal probability, stratified by centre, between a screening only control group and one of the two interventions – a single session of facetoface Personalised Feedback and Brief Advice (PFBA) or Personalised Feedback plus a smartphone or web-based brief intervention (eBI).
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Following the PICO elements, eligibility criteria included: i) participants: healthy humans aged 18 40; ii) intervention: a single bout of resistance-exercise; iii) comparator: at least one comparator group; iv) outcome: acute measures of circulating leukocyte counts.
Intervention A single 20 ml dose of the oral solution of sulfamethoxazole and trimethoprim (also known as co-trimoxazole or Bactrim; F Hoffmann-La Roche Ltd, BaSwitzerlandrlandepositedted in the PEG catheter immediately after insertion.
For various diseases clinicians have to combine different drugs or interventions when a single drug or intervention does not lead to satisfactory results.
A number of reviews studied a constellation of interventions for a single condition, such as interventions for warts [ 11].
In the field of diabetes, the review by Shojania [ 22] showed that multifaceted interventions provided a larger effect than interventions involving a single component.
These interventions occurred at various time points; in some cases, multiple interventions affected a single test.
Although two studies included two interventions against a single control [ 9, 35], in both cases only one intervention arm met our inclusion criteria.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com