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We did not find evidence that carriers of one rs1800497 T allele are at risk for obesity or reduced success during obesity intervention which needs to be discussed in context with prior results of functional neuroimaging studies by Stice et al. in which the presence of one risk allele was sufficient to modulate the relation between food reward and future weight gain [ 9, 22].
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We also highlight the various limitations and issues regarding behavioral interventions which need to be addressed and resolved.
Recent experience with Seasonal Malaria Chemoprevention and with the RTS,S/AS01 malaria vaccine provides examples of interventions which need to be deployed on a restricted rather than a national basis, taking account of differences in climate and the intensity of malaria infection between regions within a country.
The interventions which need to be delivered in health systems have been reviewed in preceding papers in this series.
Where these package adaptations occur in a study setting, particularly a randomised design, this makes the intervention an evolving one, which needs to be taken into account in trial design and reporting.
Unlike evaluation, which is undertaken at certain discrete time points after the start of an intervention, monitoring is an ongoing exercise, which needs to continue even if the effectiveness of an intervention has been proven.
Although it is not defined whether TGF- β is the universal determinants of exhaustion during persistent HBV infections, immunotherapeutic targeting IL-10 and TGF- β in CHB may provide an additional therapeutic intervention, which needs further exploration.
Pay for performance represents an inherently complex intervention with variable effects according to context, the nature of the behaviours targeted, and co-interventions, all of which need to be taken into account in planning and evaluating such schemes [ 28, 41].
Thus, there is a vast literature on interventions to help couples cope with the psychological burden of ART treatment (cf. Boivin, 2003; Hämmerli et al., 2009) and much less on interventions to diminish burden, which need to be developed and validated (Boivin et al., 2012).
Clinical research in studies involving surgical interventions presents some specific challenges, which need to be accounted for and described in the study protocol.
PEPS is a promising intervention to improve anhedonia and apathy which need to be tested further in a controlled study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com