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This outcome is unlikely in practice as it relies on the assumption that the intervention is sustained and conditions are undisturbed for 60 years.
These epidemiological predictions should, however, be interpreted with caution as they assume that the effectiveness of the intervention is sustained for many decades whereas in practice long-term effectiveness will be affected by developing drug and insecticide resistance, socio-demographic changes, and changes in control and treatment policies.
Further, the longer an intervention is sustained, the greater the likely benefit.
It is unclear whether the impact of the multifaceted intervention is sustained over time [ 27].
5 When EIS intervention is sustained, there is evidence that people with psychosis achieve better functional and social outcomes.
Such an antikindling effect has also been noted in computational studies of desynchronizing brain stimulation, including DBS. 23 The presence of adaptive effects further raises the possibility that clinical improvement with aDBS may be even greater when this intervention is sustained for periods longer than those utilized in our study.
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One involves the question of whether this intervention is sustaining life or prolonging death.
Our most important finding was that the benefits of participating in either form of intervention were sustained over many years.
In six of the nine sites, changes in HIV services implemented as a result of the organizational intervention were sustained six to nine months following the end of project implementation.
Therefore, it is important that achieved benefits of a proven effective intervention are sustained after implementation.
However, a similar intervention was sustained over a 2-year period in a study by the current investigators.
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