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An important set of topics for modeling to address are the interrelationships among intervention efficacy, intervention durability, and the effects on parasite and vector dynamics.
Varying the intervention durability profile has dramatic effects on the system, illustrating that such sensitive input parameters must be well understood to achieve accurate model results.
Sensitivity of the results of a proposed campaign to intervention durability must be understood when planning repeated rounds of distributions and cost-effectiveness.
Data collected at the interim time points will help assess effects of intensive phase of intervention (baseline to 12 months) and intervention durability throughout the maintenance phase (12 month to 24 months).
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Next, we did not measure the adherence to the intervention or the durability of the intervention.
Preliminary findings [ 14] point towards evidence for the reasonable effectiveness of the CTCH but this large scale trial will provide more definitive results about the efficacy of the intervention and the durability of its effects.
Findings provide encouraging implications regarding the long-term efficacy of interventions and the durability of symptom reduction, but must be interpreted in parallel with methodological considerations and study characteristics of RCTs.
Treatment effects were assessed post-intervention (2 months) and at 9 months, with durability of intervention effects evaluated at 18 months.
Research on the durability of the intervention effect and long-term health outcomes would facilitate cost-utility analysis.
Outcome assessment for the majority of trials occurred immediately following the intervention period and thus the durability of treatment effects are unknown.
As we move forward, the durability of our intervention will continue to be monitored: Will the effects of intensive therapy metabolic memory decrease over time?
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CEO of Professional Science Editing for Scientists @ prosciediting.com