Intervention: Diagnostic.
The most relevant included patient categories were patients with intracranial bleeding, gastrointestinal bleeding, or requiring an acute intervention (diagnostic or treatment-related).
Intervention Diagnostic upper gastrointestinal endoscopy and flexible sigmoidoscopy carried out by doctors or nurses.
Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification.
Moreover, the transition models may serve as an intervention diagnostic tool, which can be particularly beneficiary for studies failing to show significant intervention effects in abstinence rates.
We considered this hierarchy to be appropriate as it comprises levels of evidence for each type of research question (intervention, diagnostic accuracy, prognosis, aetiology, screening intervention).
A sixth category was added later to include the notion of 'safety', updating the acronym to burden of disease, investigative, prognostic, efficacy of intervention, diagnostic, and safety (BIPEDS).
Extracted data will consist of methods (dose and frequency of intervention), diagnostic description of participants and type of intervention, including target, intensity, duration and method of application (parent mediated, therapist, school based, etc).
Participants indicated the intervention diagnostic processes was acceptable to them, being frequently described as ' easy' or that they were ' happy' about the service, this was the case whether they self-presented, or were screened at home or the community.
By using the BIPEDS (Burden of disease, Investigative, Prognostic of disease, Efficacy of intervention, Diagnostic of disease, and Safety of intervention) classification of OA biomarkers [ 14, 46], we showed that SF ARGS can be categorized as a diagnostic marker for disease with the capability of distinguishing a knee injured up to 1 year after injury from knees of healthy controls [ 10].
