Sentence examples for intervention at the miRNA from inspiring English sources
We show that intervention at the miRNA level can ameliorate the negative effect of TNF-α by promoting myoblast differentiation.
The present study indicates that muscle-regulatory miRNAs are mediators of the inhibitory effect of TNF-α on skeletal muscle differentiation in vitro, and suggests that intervention at the miRNA level might be an innovative therapeutic tool to rescue the inhibitory effect of pro-inflammatory TNF-α on myoblast differentiation.
For the intervention group, sessions were scheduled to occur before the intervention (baseline), after 2.5 weeks of intervention, after 5 weeks of intervention, and at the end of the 8-week intervention period.
Precision at the mature miRNA 5' end has been reported for Drosophila miRNAs [ 44].
In contrast, we show that exogenous Polymerase III- but not Polymerase II-driven miRNAs compete with exogenous miRNAs, at multiple steps in the miRNA pathway.
Functional targets are generally fully complementary to nucleotides 2-7, preferably 2-8, athehend' end of the miRNA, referred to as the miRNA seed.
Intervention is at the Watford Palace Theatre.
505 detectable miRNA transcripts in the miRNA microarrays expressed at various time point, of which 414 miRNAs were detected at 3 h, 416 miRNAs were detected at 6 h, 396 miRNAs were detected at 12 h, 388 miRNAs were detected at 24 h, 405 miRNAs were detected at 72 h, and only 333 miRNAs were detected in all groups (Fig. 2).
In contrast, when the miRNA is located at the 3'-end of the pre-miRNA (3'-miRNA or miRNA-3p) the miRNA and the pre-miRNA have identical 3'-ends.
miRNAs are well suited to regulate cancer metastasis because of their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis cascade [43].
