Suggestions(2)
Exact(3)
Rather, the interpandemic evolution of influenza appears to consist of extended intervals of stasis, which are characterized by neutral sequence evolution, punctuated by shorter intervals of rapid fitness increase when evolutionary change is driven by positive selection.
Consistent with the excess of neutral mutations during the intervals of stasis, displacement of pre-existing lineages by new strains is slow, again suggesting that they only differ minimally in fitness.
The intervals of stasis in influenza A virus evolution are punctuated by periods of apparent rapid change in fitness (owing primarily to antigenic innovation), which are associated with an excess of nonsynonymous mutations in epitope regions of HA and the rapid displacement of old lineages by new dominant ones.
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This view would maintain an initial 35 million-year interval of stasis, or a long fuse, followed by a relatively sudden, 15 million-year interval of rapid cladogenesis from 155 to 140 Ma, toward the end of which the Glossata evolved.
Preston Cloud argued in 1948 and 1968 that the process was "explosive", and in the early 1970s Niles Eldredge and Stephen Jay Gould developed their theory of punctuated equilibrium, which views evolution as long intervals of near-stasis "punctuated" by short periods of rapid change.
This "explosive" view was supported by the hypothesis of punctuated equilibrium, which Eldredge and Gould developed in the early 1970s which views evolution as long intervals of near-stasis "punctuated" by short periods of rapid change.
In contrast, the only parallel mutations that exclusively occurred in periods of stasis (red intervals) were also the only ones to occur in non-epitope regions of the HA protein.
These long periods of stasis are punctuated by shorter intervals of rapid evolution under positive selection during which new dominant lineages quickly displace previously coexisting ones.
An additional distinction between the stasis intervals and intervals of rapid fitness change became apparent through the analysis of parallel mutations in HA, i.e., the mutations that occur on the side tree branches in parallel to those occurring on the main trunk of the tree in approximately the same time period.
These findings strongly suggest that the rapid extinction of virus lineages is driven by positive selection in the epitope regions of each new dominant lineage, whereas the intervals of slow extinction (defined here as "stasis" periods when no major antigenic changes occur) largely involve neutral or near-neutral evolution.
The intervals of open and diminished fifths, so pervasive that one begins to hear them as functionally equivalent (though qualitatively different) expressions of stasis, offset the sense of motion now assigned to a new dimension: sound traveling through space.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com