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We omitted events with a confidence interval wider than 20 ms (about 1 /4 wavelength), as they were considered to have unreliable data.
Conversely, while the GAM demonstrated the best fit and validation statistics across the three models where variable selection was performed, it had a confidence interval wider than the other models.
The uncertainty is more pronounced in the differences in QALYs, but for no group is the confidence interval wider than 1 QALY.
Unstable estimates, defined as having a 95% confidence interval wider than 15% or a width that was 40% or more than the estimate, are noted in the tables.
As trial sequential analysis relies on the accumulated number of events, the effect size, and the information size, the estimate is more conservative and the adjusted confidence interval wider but more reliable as it allows for multiple testing on accumulating data.
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NOTES: Abbreviations: MRR mortality rate ratio, CI confidence interval, Wide wide resection, Rt radiotherapy, Intra marginal/intralesional resection, Ch chemotherapy, Surg surgery.
Goel and Salganik [ 5] have suggested that RDS estimates are less accurate and confidence limit intervals wider than originally thought.
Numbers were small for these outcomes and confidence intervals wide but with a larger enrolment this risk could reach statistical significance.
Given the limited numbers of doctors either from very deprived or remote areas or working in such areas, some analytic subgroups are small and corresponding confidence intervals wide.
Finally, although numbers are small and confidence intervals wide, boys who used street drugs were almost 6 times more likely to develop self-harming behaviour.
Both confidence intervals and prediction intervals become wider for values of the predictor variable further from the mean.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com