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Although the extent of AgNP accumulation was not determined, the chorion may delay AgNP exposure to embryos, indicating that exposure characteristics regulate the time interval of toxicity occurrence between embryo and adult stages.
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The relative hazard (with 95% confidence interval) for toxicity compared with a reference group was also estimated as an indication of the strength of the possible association.
N number of subjects, D number of deaths, HR Hazard ratio, CI confident interval, Cd toxicity = Toxic effect of cadmium.
For each parameter remaining in the multivariate model, an odds ratio (OR) with 95% confidence interval (CI) for the development of toxicity was calculated.
Development of an advanced exons 45 55 skipping approach with fewer new generation AOs that have improved cardiac exon skipping activity may reduce the therapeutic dose and interval of administrations, minimising the potential toxicity, off-target effects, and the cost burden for DMD.
Maternal body weight, food and/or water consumption and signs of toxicity were monitored at regular intervals.
We tried to scrutinize the effects of toxicity, at different doses and time intervals of Bio-NPs.
Investigator assessments of toxicity are made at six-weekly intervals while on protocol treatment and scored using NCI CTC criteria (version 3.0).
While topotecan was reduced by 20% for grade 3 and by 40% for grade 4 interval hematologic toxicity for the entire course of therapy.
Besides, if the 95%% confidence interval of M includes 1, the joint toxicity was additive in nature.
Since cases of toxicity were rare, data from the >150 ng/mL " possible toxicity" interval used by ARUP were merged into the >80 ng/mL interval as they were too small to be visible when plotted on the graphs.
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