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Currently, there is a recommendation of assessment every two years (American Academy of Pediatrics, 2001); however, in our protocol, we tested yearly, and several cases were diagnosed; thus, the interval of testing should be shorter.
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Nevertheless, its application requires certain discretion in drafting the intervals of tested parameters, as the model is strictly based on linear regression.
Usually the time interval of test-retest reliability studies is chosen from one week to five weeks [ 7].
In addition, it is also understandable that the memory may affect the retest response if the time interval between the test and the retest is short; normally the time interval of test-retest reliability studies is chosen from one week to five weeks.
A high dilution of the 263K scrapie strain was used to ensure a long enough interval to test the effectiveness of the drugs to interfere with scrapie propagation.
Regular intervals of testing may be defined based on risk analysis.
Third, we did not restrict the interval between two consecutive results of testing for albuminuria.
Calculation of the mean RR interval of the tested ECGSet2 and the ECGSet1 involved in the current comparison (the smaller RR interval is further referred to as RRmin).
The MMSE and AQT changes from before baseline to baseline were thus used to calculate an interval of "normal" test changes when no treatment was given (that is, the RCI).
We also generate alternative arrival cohort intervals to test the sensitivity of the results.
To prevent bias caused by patient-to-patient transmission, we have limited the interval of repeat testing and only analyzed the first episode of test series per patient.
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