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Their appropriate PAE is critical to lengthen the interval of administration, reduce the daily dosages, and thus potentially reduce potential drug resistance.
Its use for CT is increasing, and like UGN, there is a lot of disparity, regarding the dosage (energy flux density), duration (impulses) and interval of administration of ESWT.
Therefore, intensivists must carefully consider how antibiotics are delivered in terms of dose, interval of administration, and duration of infusion in order to optimize PK/PD target attainment.
This study revealed that recovery from the deleterious effects of TA was possible, but it was dependent on both the dose and the interval of administration of TA.
The epoetin half-life and the interval of administration will be assigned to the user at the start of the exercise, while the initial haemoglobin and the patient's erythropoietin sensitivity are randomly generated by the software.
However, the administration of those antibiotics (dosing, interval of administration, duration of infusion, route of administration) should be prescribed in a manner to ensure optimal drug delivery to the site of infection.
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Development of an advanced exons 45 55 skipping approach with fewer new generation AOs that have improved cardiac exon skipping activity may reduce the therapeutic dose and interval of administrations, minimising the potential toxicity, off-target effects, and the cost burden for DMD.
Increasing the dose or reducing the intervals of administration may have additional benefit.
The dosages and intervals of administration of these drugs are routinely adjusted in patients with a diminished GFR to achieve effective treatment and to limit drug-induced toxicity.
All patients had used Lan MP 30 mg at fixed intervals of administration, for a minimum of 2 months immediately before their inclusion.
In addition to assessing delay in institution of therapy, analysis of the effect of appropriateness of therapy must take into account such issues as tissue penetration, pharmacokinetic and pharmacodynamic properties of the agent used, antimicrobial activity at varying pH, and correctness of dosing and intervals of administration.
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