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The random effects model is more conservative than the fixed effect model in the sense that the confidence interval is broader, but sometimes the point estimate is farther from the null and the P value for the pooled effect smaller than with a fixed effect model [ 31].
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Due to the fact that the results of only 19 subjects for the test could be used, it is possible that the precision of the results was less and the 95% borders of the ICC confidence interval were broader.
The predictive interval was broad but did not cross the line of no effect (1.7-89.9).
The reduction in hazard for a cardiac death for privately-funded patients was of statistical significance but the confidence interval was broad (Table 3).
Exploration for a threshold effect (table 4) showed that for a cut-off pH threshold of 7.00 the association did not reach significance overall (6.1, 0.9 to 41.6) and the predictive interval was broad (0.0-20 406.6).
We did no data pooling in cases where prediction intervals were broader than 10%%.
Moreover, the HR estimates of our additional analysis in new users of pioglitazone were in line with those of the main analysis, but the confidence intervals were broader as a result of the smaller number of patients.
While our initial models yielded some elevated risk estimates, after adjusting for multiple comparisons and breast cancer risk factors, confidence intervals were broader, as would be expected, and tended to include one.
For both species pairs, isolation times are more recent for LR loci (∼250 270 kya for both species) than for HR loci (∼350 kya for D. simulans/D. mauritiana and ∼500 kya for D. simulans/D. sechellia), although the confidence intervals are broad.
Heterogeneity between studies existed, and 95% prediction intervals were broad.
The association is statistically significant but the confidence intervals are broad (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com