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Binge drinking was associated with longer QT interval in men but not in women.
A previous study reported that high physical activity was associated with an increase in QT interval in men but not women [27].
In conclusion, data from NHANES III, a large sample representative of the general US population, found no association between QT interval duration and coffee or tea intake, smoking, physical activity and usual drinking, but suggested an association between binge drinking and longer QT interval in men.
Table 2 shows the adjusted odds ratio of HRD and its 95% confidence interval in men and women.
The fact that the strongest decrease was in the clinically relevant QTc interval in men is partly explained by the effect of RR-prolongation in the denominator of Bazett's formula for the QTc-interval.
Since the QT interval was not significantly associated with serum testosterone, our findings could suggest that the difference in the QTc interval in men is mainly due to the underlying association with the RR interval.
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These authors also suggested that only a small amount of hERG block was required to appreciably prolong the QTc interval in man.
Lower QTc intervals in men with higher serum testosterone levels could be due to the association of serum testosterone with prolongation of the RR interval.
In addition, the estimates of non-shared environmental influence in the full ACE models had non-overlapping confidence intervals in men and women (men: 72%, CI 52 91%; women: 36%, CI 25 50%).
Although the mechanisms for the differences in QT intervals in men and women are uncertain, previous studies suggest that sex hormones and differences in cardiac ionic channels or serum potassium levels may contribute to sex-specific differences in ventricular repolarization (Drici et al. 1996; Fukui et al. 2003; Liu et al. 1998).
In the Dutch prospective Doetinchem Cohort Study, cognitive functioning was measured twice within a 5-year time interval in 2,613 men and women.
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